MELS - Modular Extracorporeal Liver System
The Modular Extracorporeal Liver System is an innovative platform for liver support technology. It enables temporary extracorporeal support of patients in severe liver failure. A modular concept allows treatment with different complexicity for relevant indications of liver injury, intoxication etc. resulting in liver failure.
Clinical Application: Extracorporeal liver therapy with different modules in an integrative therapy system for individual indications according to the actual clinical needs of the patient in the time course of liver failure.
Therapy Indications: Acute decompensation of chronic liver failure: bridging to spontaneous / autonomous liver regeneration; bridging to liver transplantation; liver support after small-for-size split liver transplantation; liver support after initial dysfunction of liver transplant; patient stabilization prior to living donor split liver transplantation in fulminant liver faiure; liver support enabling extended surgery to cure liver cancer.
Technology: A modular technology platform for all relevant liver support therapies was developed. Therapy can begin early in the clinical course and the appropriate modules can be combined step by step. Modules can be upgraded as required, even during clinical application. Dialysis technologies (hepato-renal syndrome), relevant detoxification technologies (chronic liver failure) and cell-based biological support technology (acute liver failure) can be implemented. The cell module offers the patient metabolism, synthesis and regulation. The concept enables broad acceptance for extracorporeal liver support, as well as lowering the hurdles for ICUs to start more complex and technologically advanced therapies. Costs for disposables, service and technical support are reduced and handling is simplified.